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The Effects of Physical Activity on Health and Disease
Physical Activity and Health: A Report of the Surgeon General
This chapter examines the relationship of physical activity and cardiorespiratory fitness to a variety of health problems. The primary focus is on diseases and conditions for which sufficient data exist to evaluate an association with physical activity, the strength of such relationships, and their potential biologic mechanisms. Because most of the research to date has addressed the health effects of endurance-type physical activity (involving repetitive use of large muscle groups, such as in walking and bicycling), this chapter focuses on that type of activity. Unless otherwise specified, the term physical activity should be understood to refer to endurance-type physical activity. Less well studied are the health effects of resistance-type physical activity (i.e., that which develops muscular strength); when this type of physical activity is discussed, it is specified as such. Much of the research summarized is based on studies having only white men as participants; it remains to be clarified whether the relationships described here are the same for women, racial and ethnic minority groups, and people with disabilities.

Physical activity is difficult to measure directly. Three types of physical activity measures have been used in observational studies over the last 40 years. Most studies have relied on self-reported level of physical activity, as recalled by people prompted by a questionnaire or interview. A more objectively measured characteristic is cardiorespiratory fitness (also referred to as cardiorespiratory endurance) which is measured by aerobic power (see Chapter 2 for more information on measurement issues). Some studies have relied on occupation to classify people according to how likely they were to be physically active at work.

Epidemiologic studies of physical activity and health have compared the activity levels of people who have or develop diseases and those who do not. Cohort studies follow populations forward in time to observe how physical activity habits affect disease occurrence or death. In case-control studies, groups of persons who have disease and separate groups of people who do not have disease are asked to recall their previous physical activity. Cross-sectional studies assess the association between physical activity and disease at the same point in time. Clinical trials, on the other hand, attempt to alter physical activity patterns and then assess whether disease occurrence is modified as a result.

Results from epidemiologic studies can be used to estimate the relative magnitude or strength of an association between physical activity and a health outcome. Two such measures used in this chapter are risk ratio (RR) and odds ratio (OR). For these measures, an estimate of 1.0 indicates no association, when the risk of disease is equivalent in the two groups being compared. RR or OR estimates greater than 1.0 indicate an increase in risk; those less than 1.0 indicate a decreased risk. Confidence intervals (CI) reported with estimates of association indicate the precision of the estimate, as well as its statistical significance. When the CI range includes 1.0, the effect is considered likely to have occurred by chance; therefore the estimate of association is not considered statistically significantly different from the null value of 1.0.

Conclusions

Overall Mortality

  1. Higher levels of regular physical activity are associated with lower mortality rates for both older and younger adults.
  2. Even those who are moderately active on a regular basis have lower mortality rates than those who are least active.

Cardiovascular Diseases

  1. Regular physical activity or cardiorespiratory fitness decreases the risk of cardiovascular disease mortality in general and of coronary heart disease mortality in particular. Existing data are not conclusive regarding a relationship between physical activity and stroke.
  2. The level of decreased risk of coronary heart disease attributable to regular physical activity is similar to that of other lifestyle factors, such as keeping free from cigarette smoking.
  3. Regular physical activity prevents or delays the development of high blood pressure, and exercise reduces blood pressure in people with hypertension.

Cancer

  1. Regular physical activity is associated with a decreased risk of colon cancer.
  2. There is no association between physical activity and rectal cancer. Data are too sparse to draw conclusions regarding a relationship between physical activity and endometrial, ovarian, or testicular cancers.
  3. Despite numerous studies on the subject, existing data are inconsistent regarding an association between physical activity and breast or prostate cancers.

Non-Insulin-Dependent Diabetes Mellitus

  1. Regular physical activity lowers the risk of developing non-insulin-dependent diabetes mellitus.

Osteoarthritis

  1. Regular physical activity is necessary for maintaining normal muscle strength, joint structure, and joint function. In the range recommended for health, physical activity is not associated with joint damage or development of osteoarthritis and may be beneficial for many people with arthritis.
  2. Competitive athletics may be associated with the development of osteoarthritis later in life, but sports-related injuries are the likely cause.

Osteoporosis

  1. Weight-bearing physical activity is essential for normal skeletal development during childhood and adolescence and for achieving and maintaining peak bone mass in young adults.
  2. It is unclear whether resistance- or endurance-type physical activity can reduce the accelerated rate of bone loss in postmenopausal women in the absence of estrogen replacement therapy.

Falling

  1. There is promising evidence that strength training and other forms of exercise in older adults preserve the ability to maintain independent living status and reduce the risk of falling.

Obesity

  1. Low levels of activity, resulting in fewer kilocalories used than consumed, contribute to the high prevalence of obesity in the United States.
  2. Physical activity may favorably affect body fat distribution.

Mental Health

  1. Physical activity appears to relieve symptoms of depression and anxiety and improve mood.
  2. Regular physical activity may reduce the risk of developing depression, although further research is required on this topic.

Health-Related Quality of Life

  1. Physical activity appears to improve health-related quality of life by enhancing psychological well-being and by improving physical functioning in persons compromised by poor health.

Adverse Effects

  1. Most musculoskeletal injuries related to physical activity are believed to be preventable by gradually working up to a desired level of activity and by avoiding excessive amounts of activity.
  2. Serious cardiovascular events can occur with physical exertion, but the net effect of regular physical activity is a lower risk of mortality from cardiovascular disease.

Centers for Disease Control and Prevention
National Center for Chronic Disease Prevention and Health Promotion
Division of Cancer Prevention and Control

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